《生命科学》 2012, 24(10): 1169-1173

TRPC1和Ca2+在帕金森病内质网应激中的作用

邓　娟，白　洁^*

(昆明理工大学医学院，昆明650500)

摘　要：

摘　要：帕金森病是一种常见的神经系统退行性疾病，内质网应激在帕金森病发病过程中具有重要的作用。瞬时受体电位阳离子通道1(transient receptor potential channel 1， TRPC1)是非选择性的阳离子通道，主要位于细胞膜上，可以调节Ca2+的内流和抑制内质网应激所致的神经元凋亡。Ca2+是细胞内重要的第二信使，其浓度的稳定对维持细胞的功能起着重要作用。内质网是细胞内Ca2+储存的重要细胞器。因此，TRPC1和Ca2+在帕金森病中起着重要作用。综述了TRPC1和Ca2+与帕金森病内质网应激的相关进展。

    

关键词：TRPC1； Ca2+；帕金森病；内质网应激

    

中图分类号：R742.5；Q73　　文献标志码：A

    

 

The role of TRPC1 and Ca2+ in the endoplasmic reticulum stress of Parkinson′s disease

DENG Juan， BAI Jie^*

(Medical Faculty， Kunming University of Science and Technology， Kunming 650500， China)

Abstract:

Abstract: Parkinson′s disease is a common neurodegenerative disease. Endoplasmic reticulum stress plays an important role in the pathogenesis of Parkinson′s disease. Transient receptor potential channel 1 (TRPC1) is a non-selective cation channel which locates in the cell membrane， and regulates Ca2+ influx and plays roles in inhibiting apoptosis by endoplasmic reticulum stress. Ca2+ is an important intracellular second messenger， and the balance of Ca2+ level plays important roles in sustaining cellular functions. Endoplasmic reticulum is an important organelle of storing Ca2+. Therefore， TRPC1 and Ca2+ play an important role in Parkinson′s disease. This paper reviews the progress in relationship between the TRPC1， Ca2+ and endoplasmic reticulum stress in Parkinson′s disease.

    

Key words: TRPC1; Ca2+; Parkinson′s disease; endoplasmic reticulum stress

    

收稿日期：2012-04-20； 修回日期：2012-05-21

    

基金项目：国家自然科学基金项目(81160162)

    

*通信作者：E-mail: jiebai662001@yahoo.com.cn