《生命科学》 2012, 24(10): 1151-1156

PPARγ辅调节因子与脂代谢关系的研究进展

齐美玲，赵　越^*

(中国医科大学，教育部医学细胞生物学重点实验室暨卫生部细胞生物学重点实验室，染色质生物学研究室， 沈阳 110001)

摘　要：

 摘　要：代谢综合征包括脂代谢异常、向心性肥胖、胰岛素抵抗和2型糖尿病等多种代谢异常疾病，严重威胁着人们的健康和生活质量。 PPARγ的辅调节因子通过调控PPARγ介导的基因转录参与脂代谢调节，其中PGC-1α通过调控PPARγ介导的下游靶基因的转录等环节，参与调节多种脂代谢通路；SMRT、TRAP和JHDM2a也通过不同的机制调节PPARγ介导的基因转录，参与脂代谢调节。

    

关键词：PPARγ；辅调节因子；转录调控；脂代谢异常

    

中图分类号：Q591; Q756 文献标识码：A

Co-regulators of PPARγ and lipid metabolism

QI Mei-Ling， ZHAO Yue^*

(Laboratory of Chromatin Biology， Department of Cell Biology， Key Laboratory of Public Health Ministry of China， Department of Medical Cell Biology of Ministry of Education， China Medical University， Shenyang 110001， China)

Abstract:

Abstract: Metabolic syndrome is characterized by dyslipidemia， centripetal obesity， insulin resistance and type 2 diabetes and so on， which affecting people’s health and life quality seriously. Peroxisome proliferation -activated receptors (PPARs)， which are ligand-dependent transcriptional factors， belong to the nucleur receptor superfamily. PPARγ is a central regulators of adipogenesis， and plays an important role in the lipid metabolism. Co-regulators of PPARγ are involved in the lipid metabolism through its modulation of PPARγ-mediated transactivation. PGC-1α widely participates in regulation of various lipid metabolic pathways by modulating the downstream target genes controlled by the PPARγ. SMRT， TRAP and JHDM2a are also involved in the regulation of lipid metabolism by modulation PPARγ-mediated transactivation in the different way.

    

Key words: PPARγ; co-ragulators; transcription regulation; abnormal lipid metabolism