《生命科学》 2012, 24(10): 1075-1081

DC-SIGN固有免疫调节及其表达调控机制研究进展

任建敏，张彦洁，王俊青，吴　菁，刘昕訸，杨　芬，许春娣，周　同^*

(上海交通大学医学院附属瑞金医院，上海 200025)

摘　要：

 摘　要：DC-SIGN (DC-specific ICAM-3-grabbing non integrin， CD209)系C型凝集素家族主要成员，具有模式识别受体和介导细胞黏附功能。DC-SIGN可通过分子中凝集素糖识别域，识别多种病原体的外源性和机体内源性抗原以及细胞表面黏附分子(ICAM-2， 3)中甘露糖或岩藻糖的糖基团，并对话协调Toll 样受体等，介导树突状细胞(DC)等参与病原体或肿瘤细胞的免疫逃逸；也可调节DC黏附迁移并在炎症启动中激活初始T细胞免疫应答。因而，作为天然免疫分子介导基础，DC-SIGN在DC参与的感染性和炎症性疾病等的正负免疫调节中发挥了关键作用。目前有关DC-SIGN免疫调节效应涉及的信号转导以及分子表达调控机制尚未完全阐明，就相关进展作一综述。关键词：DC-SIGN；免疫调节；信号转导；表达机制

    

中图分类号：R392.12    文献标志码：A

    

 

Research progress on DC-SIGN medicated innate immunoregulation and regulatory mechanism of its expression

REN Jian-Min， ZHANG Yan-Jie，WANG Jun-Qing，WU Jing， LIU Xin-He， YANG Fen， XU Chun-Di， ZHOU Tong^*

(Ruijin Hospital， Shanghai Jiaotong University School of Medicine， Shanghai 200025， China)

Abstract:

Abstract: DC-SIGN (dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin) belongs to the major members of C-type lectin family， which is a PRR (pattern recognition receptor) and can mediate cell adhesion. DC-SIGN can specifically recognize glycoconjugates containing mannose or fucose in various exogenous antigen of pathogens， endogenous self-antigen and intercellular adhesion molecule 2，3 (ICAM-2， 3) by its lectin carbohydrate recognition domain. Moreover， it is also involved in immune escape of tumor cell or pathogens mediated by dendritic cells (DCs) through cross-talking with Toll like receptors. In the initial response of inflammation， DC-SIGN modulates the adhesion and migration of DCs to activate naive T-cell. Therefore， as an innate immune molecule， DC-SIGN plays an crucial role in infectious and inflammatory diseases through its positive and negative immunoregulatory effects on DCs. However， the immunoregulation mechanisms of DC-SIGN including signal transduction and expression regulation have not been fully elucidated. We have reviewed some progress in this field here.

    

Key words: DC-SIGN; immunoregulation; signal transduction; expression mechanism