《生命科学》 2012, 24(7): 674-679

NF-κB信号和MAPK通路在椎间盘退变中的研究进展

刘玉亮¹，殷　明^2*，梁广胜¹，董　理¹，何丁文¹

(1 南昌大学医学部研究生院，南昌 330006；2 南昌大学第二附属医院骨科，南昌 330006)

摘　要：摘　要：椎间盘退变涉及诸多因素，其中由细胞外基质分解代谢和合成代谢失衡导致的基质减少发挥了很大的作用，但这些变化的发生还没被全部阐明。由丝裂原活化蛋白激酶(MAPK) 和核因子kappaB(NF-κB)通路介导的细胞因子在代谢失衡中发挥重要作用，所以，研究细胞因子产生作用的信号转导通路对深入了解椎间盘退变的原因及为其治疗提供了新的方向。对NF-κB 和MAPK 信号转导通路及其在椎间盘退变中的作用机制加以综述。
关键词：椎间盘退变；丝裂原活化蛋白激酶；核因子κB ；细胞因子

MAPK and NF-κB signal transduction pathways in intervertebral disc degeneration

LIU Yu-Liang¹， YIN Ming^2*， LIANG Guang-Sheng¹， DONG Li¹， HE Ding-Wen¹

(1 Graduate School of Medicine， Nanchang University， Nanchang 330006， China; 2 Second Affiliated Hospital of Nanchang University， Nanchang 330006， China)

Abstract: Abstract: Many factors involve in the intervertebral disc degeneration(IDD)， the decrease of the disc extracellular matrix induced by the imbalance between anabolism and catabolism plays a significant role in this procedure. However， the reasons of these changes have not been fully elucidated. Cytokines mediated by the mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NF-κB) pathways play a significant role in the metabolic imbalance. Therefore， to study these signaling pathways provides a novel direction for understanding the causes and the treatment of IDD. This article summarizes MAPK and NF-κB signal transduction pathways and their role in IDD.
Key words: intervertebral disc degeneration(IDD); mitogen-activated protein kinase (MAPK); nuclear factor kappaB (NF-κB); cytokine