《生命科学》 2012, 24(7): 660-665

miR-34家族在慢性淋巴细胞白血病中的作用

曹　烨¹，孙志卫²，梁　拓¹，刘　静^2*

(1 中南大学生物科学与技术学院，长沙 410013；2 中南大学生物科学与技术学院分子生物学研究中心，长沙 410078)

摘　要：摘　要：近年来的研究表明microRNAs 表达异常直接或间接导致了多种亚型慢性淋巴细胞白血病(chronic lymphocytic leukemia， CLL) 的发生。miR-34 家族( 包括miR-34a、miR-34b 与miR-34c) 是一个与细胞增殖、分化和癌变高度相关的microRNA 家族。近年来，人们发现miR-34 家族在p53 调控网络和CLL 发生中起着重要作用，并具有显著的临床应用价值。将对miR-34 家族在慢性淋巴细胞白血病发生中的作用和机制做一综述。
关键词：miR-34 家族; 慢性淋巴细胞白血病；p53 ；化学治疗抗性

The effect of miR-34 family on chronic lymphocytic leukemia

CAO Ye¹， SUN Zhi-Wei²， LIANG Tuo¹， LIU Jing^2*

(1 School of Biological Science and Technology， Central South University， Changsha 410013， China; 2 Molecular Biology Research Center， School of Biological Science and Technology， Central South University， Changsha 410078， China)

Abstract: Abstract: Recent research demonstrates that the expression abnormity of microRNAs， directly or indirectly， results in the occurrence of chronic lymphocytic leukemia (CLL) of various subtypes. MiR-34 family， including miR-34a， miR-34b and miR-34c， is a microRNA family closely relating to cell proliferation， differentiation and cancerization. Recently， researchers found that miR-34 family plays an important role in the regulatory network of p53 and CLL pathology. Meanwhile， its clinical value also reveals. In this review， the role of miR-34 family in the pathological
process of CLL is expounded.
Key words: miR-34 family; chronic lymphocytic leukemia; p53; chemotherapy resistance