《生命科学》 2012, 24(7): 653-659

组蛋白甲基化修饰酶与早期胚胎发育

张武文，李逸平^*

(中国科学院上海生命科学研究院，生物化学与细胞生物学研究所，上海市分子男科学重点实验室，中国科学院分子细胞生物学重点实验室，上海 200031)

摘　要：摘　要：早期胚胎发育是胚胎发育中细胞分裂与分化最为活跃的时期，也是合子型基因大规模转录的时期，而此时组蛋白的甲基化修饰也显示出动态学的变化。这一时期，在细胞内外信号的共同调控下，经历着一系列基因的激活与抑制，许多调控机制参与其中的调控。而近年来的研究表示，表观遗传学调控显示越来越重要的作用。组蛋白甲基化修饰是表观遗传学重要调控机制之一，在胚胎的早期发育过程中扮演着重要的角色。就近年来组蛋白甲基化修饰酶在早期胚胎发育过程中的作用与功能做一简要综述。
关键词：胚胎发育；甲基化修饰；甲基化酶；去甲基化酶；表观遗传

Histone methylated modification enzyme and early embryo development

ZHANG Wu-Wen， LI Yi-Ping^*

(State Key Laboratory of Cell Biology， Shanghai Key Laboratory for Molecular Andrology， Institute of Biochemistry and Cell Biology， Shanghai Institutes for Biological Sciences， Chinese Academy of Sciences， Shanghai 200031， China)

Abstract: Abstract: Early embryo development is the most active stage for cell division and differentiation. It is a stage for initiation of large-scale transcription of zygotic genes. At this time， there is also dynamic variation in histone methylated modification. There are some extracellular and intracellular signals working cooperatively to regulate a series of genes expression and repression， many mechanisms participated in this regulation. In recent studies， the regulation of epigenetics has been shown to play an important role in these biological processes. Histone methylated modification is one of the key epigenetic regulation mechanisms that play critical roles in early embryo developmental programs. This review summarized recent advances in the understanding of role and function of
histone methylated modification enzyme during the course of early embryo development.
Key words: embryo development; methylated modification; methylase; demethylase; epigenetics