《生命科学》 2012, 24(7): 640-645

ILT受体在HLA-G参与免疫耐受机制中的研究进展

许惠惠，林爱芬，颜卫华^*

(温州医学院附属浙江省台州医院中心实验室，临海 317000)

摘　要：摘　要：免疫球蛋白样转录物(immunoglobulin-like transcript， ILT) 家族表达于髓系和淋系细胞表面，功能上可分为抑制性或激活性受体两大类，通过与相应的配体结合诱导免疫抑制或免疫应答作用。ILT2/4 受体通过与其配体人类白细胞抗原-G (human leukocyte antigen-G， HLA-G) 相互作用，传递抑制信号，调节免疫活性细胞的生物学功能或诱导耐受型DC 细胞(tolerogenic dendritic cells， tDC)/ 调节性T 细胞(regulatory T cells， Treg)/ 髓系衍生抑制性细胞(myeloid-derived suppressor cells， MDSCs) 的产生。就ILTs 受体在HLA-G免疫耐受机制中的研究进展作一综述。
关键词：ILT2 ；ILT4 ；HLA-G ；信号通路；免疫耐受

Roles of immunolglobulin-like transcript family receptors and HLA-G binding in immune tolerogenic regulation

XU Hui-Hui， LIN Ai-Fen， YAN Wei-Hua^*

(Laboratory Center， Wenzhou Medical College Affiliated Taizhou Hospital of Zhejiang Province， Linhai 317000， China)

Abstract: Abstract: The immunolglobulin-like transcript (ILT) family of proteins are surface receptors expressed by myeloid and lymphoid cells， including inhibitory receptors and activated receptors. Its interaction with corresponding ligands could induce immunosuppression or immune activation in various condictions. The interaction of the ligand human leukocyte antigen-G and ILT2/4 promotes immune suppressive activity and induces tolerogenic dendritic cells and regulatory T cells or myeloid-derived suppressor cells (MDSCs). Here we discuss the recent studies on the roles of immunolglobulin-like transcript family receptors in tolerogenic immune regulation with their interaction with HLA-G.
Key words: ILT2; ILT4; HLA-G; signaling pathway; immunotolerance