《生命科学》 2012, 24(6): 583-587

胰腺星状细胞活化相关的信号转导通路

陈碧君，孙子林，李凤飞，杨家悦，李　玲^*

(东南大学附属中大医院内分泌科，东南大学糖尿病研究所，南京 210009)

摘　要：摘　要：胰腺纤维化是慢性胰腺炎(chronic pancreatitis， CP)和胰腺癌主要的病理学特征，活化的胰腺星状细胞(pancreatic stellate cells， PSCs)是公认的致胰腺纤维化的主要效应细胞。PSCs 的活化涉及到几个重要的信号转导通路：有丝分裂原活化蛋白激酶(mitogen-activated protein kinases， MAPK)、 磷酯酰肌醇3激酶 (phosphatidylinositol 3-kinase， PI3K)=、 Smad信号转导蛋白、过氧化物酶体增生物激活受体-γ (PPAR-γ)、 Rho-ROCK 等细胞内信号途径。探讨这些信号通路在胰腺纤维化中所起的作用对慢性胰腺炎、胰腺癌及糖尿病的治疗有重要意义。现就与 PSCs 激活有关的信号通路的研究结合最新进展作一综述。
关键词：胰腺星状细胞；信号转导；胰腺纤维化

The signaling pathways in pancreatic stellate cells

CHEN Bi-Jun， SUN Zi-Lin， LI Feng-Fei， YANG Jia-Yue， LI Ling^*

(Department of Endocrinology， Zhongda Hospital， Institute of Diabetes， Southeast University， Nanjing 210009， China )

Abstract: Abstract: Pancreatic fibrosis is one of the dominant pathological characters of chronic pancreatitis and pancreatic cancer. Activated pancreatic stellate cells (PSCs) play a pivotal role in pancreatic fibrosis. The activation of PSCs is regulated by several signaling transduction pathways: mitogen-activated protein kinases (MAPK)， phosphatidy-linositol 3-kinase (PI3K)， Smad signaling transduction protein， peroxisome proliferator-activated receptor (PPAR)， Rho-ROCK. Identification of signaling molecules that play a crucial role in PSCs activation is important for the development of anti-fibrotic therapies. This review aims at summarizing the signaling transduction pathways that associated with the activation of PSCs and highlighting the recent advancements.
Key words: pancreatic stellate cells; signaling transduction; pancreatic fibrosis