《生命科学》 2012, 24(6): 578-582

HLA-F研究进展

徐丹萍，林爱芬，颜卫华^*

(温州医学院附属浙江省台州医院中心实验室，临海 317000)

摘　要：摘　要：人类白细胞抗原(human leucocyte antigen， HLA)复合体是人体中基因多态性最高的基因复合体，其多态性与疾病遗传易感性显著相关。人类白细胞抗原-F (human leucocyte antigen-F， HLA-F)属于非经典HLA I类分子中的一员，与HLA-E、-G在结构上十分相似，具有有限的多态性。近年来多数学者聚焦于HLA-F基因转录及分子表达调控、HLA-F表达与临床相关性及HLA-F抗体研制，且取得了重要成果。就HLA-F的研究进展作一综述。
关键词：HLA-F；调控；基因多态性

Research advances of HLA-F

XU Dan-Ping， LIN Ai-Fen， YAN Wei-Hua^*

(Laboratory Center， Wenzhou Medical College affiliated Taizhou Hospital of Zhejiang Province， Linhai 317000， China)

Abstract: Abstract: Human leukocyte antigen complex with the highest gene polymorphisms in human， is significantly associated with genetic susceptibility to diseases. Human leukocyte antigen-F belongs to the non-classical HLA I molecules. HLA-F， HLA-E and HLA-G have a similar structure and a limited polymorphism. In recent years， transcription regulation of HLA-F， expression regulation of HLA-F in cell surface， clinical relevance of HLA-F and the preparation of anti-HLA-F， are widely studied and have achieved important results. In the present review， the research advances on HLA-F are discussed.
Key words: HLA-F; regulation; gene polymorphism