《生命科学》 2012, 24(6): 568-577

NOX家族蛋白的研究进展

韩晓燕¹，高丽萍¹， 刘　箐^2*

(1 兰州大学基础医学院生物化学与分子生物学研究所，兰州 730000；2 上海理工大学医疗器械与食品学院，上海 200093)

摘　要：摘　要：NADPH氧化酶催化亚基gp91phox(NOX2)及其同源物NOX1、NOX3、NOX4、NOX5、DUOX1和DUOX2统称为NOX家族，它们作为NADPH酶的核心亚基，是该酶发挥作用的关键。NOX家族几乎存在于所有的细胞，吞噬细胞中NADPH氧化酶生成的ROS主要起细胞防御功能，与此不同的是非吞噬细胞中NADPH氧化酶产生的ROS作为信号分子，参与机体内信号转导途径，调节细胞分化、增殖、衰老和凋亡等活动；当NOX家族蛋白异常表达，ROS水平急剧增加时，则能诱导机体内多种疾病的发生。
关键词：NOX家族；ROS；表达；结构；活化；功能

The development of NOX family proteins

HAN Xiao-Yan¹， GAO Li-Ping¹， LIU Qing^2*

(1 Department of Biochemistry and Molecular Biology， School of Basic Medical Sciences， Lanzhou University， Lanzhou 730000， China; 2 School of Medical Instrument and Food Engineering， University of Shanghai for Science and Technology， Shanghai 200093，China)

Abstract: Abstract: The catalytic subunit gp91phox (NOX2) of NADPH oxidase and its homologues NOX1， NOX3， NOX4， NOX5， DUOX1 and DUOX2 are collectively referred to as the NOX family. NOX family proteins play a key role in NADPH oxidase function as the core subunits of the NADPH enzyme. In recent years， a large number of studies show that NOX family proteins exist in almost all cells. NADPH oxidase-generated ROS plays a cellular defense function in the phagocytic cells， the difference is that the ROS is generated by NOX family in non-phagocytic cells as a signaling molecule， involving in signal transduction and regulating cell differentiation， proliferation， senescence and apoptosis. When the abnormal expression of NOX family proteins lead to a sharp increase in ROS levels， the oxidative stress can induce many diseases.
Key words: NOX family; ROS; structure; expression; activation; function