《生命科学》 2012, 24(6): 558-567

神经递质转运蛋白在应激性心肌病发病中的潜在作用

李　贺^1*，周　欣¹，彭　朋²，何　冰²，王得顺¹，胡　冰¹，郑淑芳¹

(1 武警医学院附属医院，武警部队心血管病研究所，天津 300162；2 武警医学院，天津市职业与环境危害生物标志物重点实验室，天津 300162)

摘　要：摘　要：应激性心肌病是强烈应激诱发的心血管急症，自20世纪90年代初 Dote首次报告后，世界各地临床报告病例逐年攀升。发病机制迄今尚不完全清楚，但交感神经过度激活，大量释放去甲肾上腺素在本病发生中起重要作用。根据相关研究进展，主要综述神经递质转运蛋白调控神经递质及交感神经活性在这一神经源性心脏病中可能发挥的重要作用。
关键词：应激性心肌病；神经递质转运蛋白；去甲肾上腺素；γ-氨基丁酸；交感神经

Potential role of neurotransmitter transporters on stress cardiomyopathy

LI He^1*， ZHOU Xin¹， PENG Peng²， HE Bing²， WANG De-Shun¹， HU Bing¹， ZHENG Shu-Fang¹

(1 Hospital Affiliated Logistical College of CAPF， Institute of Cardiovascular Diseases of CAPF， Tianjin 300162， China;2 Logistical College of CAPF， Tianjin 300162， China)

Abstract: Abstracts: Stress cardiomyopathy is an acute severe cardiovascular syndrome triggered by an emotionally or physically stressful event， also known as takotsubo cardiomyopathy has aroused interest in the cardiology community since it was first described by Dote in Japan in 1990. An increasing number of cases of the cardiomyopathy， mainly occurring in elderly women recently， have been documented in many parts of the world. Although the exact mechanism of stress cardiomyopathy remains not fully understood， it appears that the activation of the sympathetic nervous system， resulting in a surge of catecholamines due to severe emotional or acute physical disease， probably plays a central role in the pathology of this condition. This review primarily addresses the potential role of neurotransmitter transporters involved with pathogenesis of the neurogenic heart disease.
Key words: stress cardiomyopathy; neurotransmitter transporter; norepinephrine; γ-aminobutyric acid; sympathetic nerve