《生命科学》 2012, 24(5): 456-462

核呼吸因子的研究进展

张　佐¹，肖位忠²，舒青龙¹，姚鹏程¹，彭淑红^1*

(1 江西中医学院，南昌 330004；2 江西省南昌市疾病预防控制中心，南昌 330038)

摘　要：摘　要：核呼吸因子(nuclear respiratory factors，NRFs) 包括NRF-1 和NRF-2，属于转录激活因子，在调控核基因编码和线粒体基因编码的呼吸链亚基表达中发挥着直接或间接的作用。除此之外，核呼吸因子还具有调控线粒体运输蛋白基因表达和神经元相关因子合成的作用。就NRF-1 和NRF-2 的分子生物学结构、生物学功能和调控等三个方面进行综述。
关键词：NRF-1 ；NRF-2 ；线粒体转录因子；转录激活

Progress of nuclear respiratory factors

ZHANG Zuo¹， XIAO Wei-Zhong²， SHU Qing-Long¹， YAO Peng-Cheng¹， PENG Shu-Hong^1*

(1 Jiangxi University of Traditional Chinese Medicine， Nanchang 330004， China; 2 Nanchang Center for Disease Control & Prevention， Nanchang 330038， China)

Abstract: Abstract: Nuclear respiratory factors (NRFs) are transcriptional activators which include NRF-1 and NRF-2. They play direct or indirect roles in regulating nuclear encoded and mitochondrial encoded respiratory genes expression. In addition， nuclear respiratory factors regulate the gene expression of translocase outer mitochondrial membrane (TOMM) and the synthese of neuron associated factors. The molecular structure， functions and regulation of NRFs will be reviewed in this paper.
Key words: NRF-1; NRF-2; mitochondrial transcriptional factors; transcriptional activation