《生命科学》 2012, 24(5): 439-443

LEF-1的调控及其与肿瘤的关系研究进展

崔婷婷，谢　楠，张小莉，吴琴丰，聂红娟，杨敏敏，陈亦雯，侯颖春^*

(陕西师范大学生命科学学院，陕西 710062)

摘　要：摘　要：淋巴细胞增强因子(lymphoid enhancer factor， LEF-1) 是Wnt 信号通路中的一个重要调控因子。其异常表达对肿瘤细胞增殖和凋亡调控起关键作用。LEF-1 作为Wnt 信号通路核内的转录因子，还与T 细胞受体α (TCRα) 的增强子相互作用形成特定的构象，从而与其他因子结合共同调节基因的表达。同时，LEF-1 为一多启动子基因，编码产生致瘤的全长形式的LEF-1 和对Wnt 信号通路起负向调控作用的截短形式的LEF-1。诸多研究结果表明肿瘤的发生发展与LEF/TCF 各亚型的比例有关。就Wnt/LEF-1 信号通路的调控以及与肿瘤的关系做一综述。
关键词：LEF-1 ；Wnt 信号通路；调控；肿瘤

Advances of the study on the regulation of Wnt/LEF-1 signal pathway and the relation with tumor

CUI Ting-Ting， XIE Nan， ZHANG Xiao-Li，WU Qin-Feng， NIE Hong-Juan， YANG Min-Min， CHEN Yi-Wen， HOU Ying-Chun^*

(College of Life Sciences， Shaanxi Normal University， Xi’an 710062， China)

Abstract: Abstract: LEF-1 is an important regulator in Wnt signaling pathway， its abnormal expression plays a key role in the cell proliferation and apoptosis， especially for the tumor cells. As a key regulator of Wnt signaling pathway， the specific conformation assembled by LEF-1 and T cell receptor α (TCRα) enhancer regulates gene expression with other factors together. Additionally， LEF-1 is a multi-promoter driving gene and encodes a full-length form of the LEF-1 involving in oncogenesis and a truncated form of the LEF-1 regulating Wnt signaling pathway negatively. Reported data shows that the oncogenesis and tumor development are closely associated with the expression level change of LEF / TCF subtypes. We review the recent advances about LEF-1 as a regulator in Wnt pathway and its relationship with oncogenesis and progression of tumors in this paper.
Key words: LEF-1; Wnt signal pathway; regulation; tumor