《生命科学》 2012, 24(5): 434-438

鸟氨酸脱羧酶与肿瘤

张贺吉，韩　钰，王艳林^*

(三峡大学分子生物学研究所，三峡大学医学院，宜昌 443002)

摘　要：摘　要：多胺是广泛存在于哺乳类组织细胞中的小分子有机化合物，参与细胞的生长和分化等重要的生理过程，也是肿瘤细胞的快速生长所必需。鸟氨酸脱羧酶(ornithine decarboxylase， ODC) 是多胺合成代谢途径中的第一个限速酶， ODC 活性的异常会引起包括肿瘤在内的一系列疾病的发生，由此该酶成为近年来研究的热点。简要综述了ODC 与肿瘤关系的研究进展。
关键词：鸟氨酸脱羧酶；多胺代谢；肿瘤治疗

Ornithine decarboxylase and tumor

ZHANG He-Ji， HAN Yu， WANG Yan-Lin^*

(Institute of Molecular Biology， Medical College， Three Gorges University， Yichang 443002， China)

Abstract: Abstract: Polyamines are small organic compounds， which widely exist in the mammalian tissues and involve in many important physiological functions including cell growth and differentiation. They are also needed for the rapid growth of the tumor cells. Ornithine decarboxylase (ODC) is the first rate-limiting enzyme in the polyamine synthetic pathway. Dysfunction of ODC is related to lots of diseases including tumors， which made this enzyme a hot study field. This article briefly reviews the research progress of the relationship between ODC and tumor.
Key words: ornithine decarboxylase; polyamine metabolism; cancer treatment