《生命科学》 2012, 24(5): 428-433

微RNA在卵巢上皮性癌发生发展中作用及其临床意义

程　妮¹，朱耀魁^1*，张　磊²，岑颖洲²

(1 暨南大学附属第一医院妇产科，广州 510632；2 暨南大学生命科学技术学院化学系，广州 510632)

摘　要：摘　要：研究表明，miRNA 参与了胚胎发育、损伤修复、糖尿病、心脏病等许多重要生理病理过程，特别是在恶性肿瘤的发生发展中发挥了重要作用，并具有潜在的临床意义。本文比较详细地叙述了有关miRNA的重要基础研究成果，并就miRNA 在卵巢癌组织及细胞中的表达、miRNA 在卵巢癌发生发展中的作用、miRNA 与卵巢癌早期诊断、化疗耐药及预后判断等方面的最新研究成果进行了综述。
关键词：微RNA ；卵巢上皮性癌；发病机理；临床意义

The roles of miRNAs in the pathogenesis of epithelial ovarian cancer and its clinical significance

CHENG Ni¹， ZHU Yao-Kui^1*， ZHANG Lei²， CEN Ying-Zhou²

(1 Department of Obstetrics and Gynecology， First Affiliated Hospital， Jinan University， Guangzhou 510632， China; 2 Department of Chemistry， College of Life Science and Technology， Jinan University， Guangzhou 510632， China)

Abstract: Abstract: Previous studies show that miRNAs have participated in numerous pathophysiological processes such as embryonic development， injury repair， diabetes and heart desease. Particularly， miRNAs play an extremely important role in the pathogenesis of malignant tumor and possess numerous potential clinical significance. The miRNA expression profile in the tissue sample and cell lines of epithelial ovarian cancer(EOC) has been determined and the mechanism by which miRNAs act in the pathogenesis of EOC has been preliminarily investigated. Those other latest advances in term of miRNAs and early diagnosis and chemotherapy resistance and prognosis prediction of EOC were also reviewed in this paper.
Key words: miRNA; epithelial ovarian cancer; pathogenesis; clinical significance