《生命科学》 2012, 24(5): 411-414

硒蛋白S基因多态性研究进展

陈小丹^1，2，张小爱²，吴志豪³，胡平成^1*

(1 中南大学公共卫生学院流行病与卫生统计学系，长沙 410078；2 军事医学科学院微生物流行病研究所病原微生物生物安全国家重点实验室，北京 100071；3 军事医学科学院疾病预防控制所，北京 100071)

摘　要：摘　要：硒蛋白S (selenoprotein S， SELS) 是一种在内质网和细胞膜潴留的硒蛋白，是一种新发现的炎症负调控因子，可以保护细胞免受氧化损伤，参与炎症和免疫反应。SELS 基因多态性与肿瘤、心血管疾病、缺血性中风和先兆子痫等疾病的发生风险相关。简要介绍SELS 的生物学功能，并对近年来SELS 基因多态性与疾病易感性的研究进行回顾。
关键词：硒蛋白S ；基因多态性；遗传易感性；炎症

Progress of the study on genetic polymorphisms of selenoprotein S

CHEN Xiao-Dan^1，2， ZHANG Xiao-Ai²， WU Zhi-Hao³， HU Ping-Cheng^1*

(1 Department of Epidemiology and Health Statistics， School of Public Health， Central South University，Changsha 410078， China; State Key Laboratory of Pathogen and Biosecurity， Beijing Institute of Microbiology and Epidemiology， Beijing 100071， China; 3 Institute of Disease Control and Prevention， Academy of Military Medical Sciences， Beijing 100071， China)

Abstract: Abstract: Selenoprotein S (SELS) is a kind of selenoprotein located in the endoplasmic reticulum (ER) and the plasma membrane. It has been identified as a new negative regulator of inflammatory cytokine. It could protect cells from oxidative damage， participate in the regulation of inflammatory and immunity response. Previous studies have shown that polymorphisms of SELS are associated with the risk of cancers， coronary heart disease， stroke， and preeclampsia. In this review， the biological role of SELS is discussed， and the recent dvances of the SELS polymorphisms as well as their associations with the susceptibility to many diseases are summarized.
Key words: selenoprotein S; polymorphism; susceptibility; inflammation