《生命科学》 2012, 24(4): 385-389

信号分子ppGpp与微生物环境适应性

卢文珺，王金文，徐　俊^*

(上海交通大学生命科学技术学院微生物代谢国家重点实验室，上海200240)

摘　要：摘　要：微生物能感知环境胁迫信号，通过触发严谨反应对生长速率进行调节，并通过一系列代谢调控，使细胞能在不利环境中生存。高度磷酸化的鸟苷四/五磷酸ppGpp/pppGpp (文中以ppGpp统称)作为信号分子对微生物生理具有广泛的调节作用，至今仍是微生物学研究热点之一。ppGpp对于微生物适应高温、高压等环境起到了积极的作用。综述了信号分子ppGpp合成降解机制及其调控微生物适应性方面的研究进展。
关键词：ppGpp；严谨反应；环境适应性

Alarmone ppGpp and its role in the environmental adaptations of microorganisms

LU Wen-Jun， WANG Jin-Wen， XU Jun^*

(State Key Laboratory of Microbial Metabolism， School of Life Science & BiotechnologyShanghai Jiaotong University， Shanghai 200240， China)

Abstract: Abstract: When microorganism confronted with unfavorable environment， it can perceive the stress signal and start stringent response quickly to make bacteria more adaptive to all kinds of environment. The guanosine tetraphosphate ppGpp is the most celebrated alarmone to trigger the gene regulation for environmental adaptation according to its physiological status in prokaryote. ppGpp plays an active role especially in extreme environment adaptation， i.e. stress response to high temperature， high pressure et al. This paper reviews the mechanism of ppGpp regulation and the recent progress on the causal relationship between ppGpp and various environmental adaptations.
Key words: ppGpp; stringent response; environmental adaptation