《生命科学》 2012, 24(4): 368-373

腺苷-磷酸激活的蛋白激酶在脂类营养代谢中的研究及应用

袁国铖^1，2，周凌云^1*，南雪梅¹，胡　菡¹，崔瑞莲¹

(1 中国农业科学院北京畜牧兽医研究所，动物营养学国家重点实验室，北京 100193；2 甘肃农业大学动物科学技术学院，兰州 730070)

摘　要：摘　要：腺苷-磷酸激活的蛋白激酶(AMP-activated protein kinase， AMPK)是公认的重要能量感受酶。其作用与多个代谢途径有关，尤其在脂类营养代谢过程中发挥着关键的调控作用。AMPK对脂质代谢的调控通过多个信号通路进行，涉及到骨骼肌、肝脏、乳腺等多个组织。对AMPK调控脂类营养代谢机理的研究为2型糖尿病、脂肪肝、肥胖症、癌症等多种疾病的治疗提供了靶点，但AMPK在奶牛乳腺组织的研究较少，其在提高奶牛生产性能方面潜能巨大。
关键词：AMPK；脂质代谢；信号通路

The role of AMP-activated protein kinase in the lipids metabolism

YUAN Guo-Cheng^1，2， ZHOU Ling-Yun^1*， NAN Xue-Mei¹， HU Han¹， CUI Rui-Lian¹

(1 Institute of Animal Sciences， State Key Lab of Animal Nutrition， Chinese Academy of Agricultural Sciences， Beijing 100193， China; 2 College of Animal Science and Technology， Gansu Agricultural University， Lanzhou 730070， China)

Abstract: Abstract: The AMP-activated protein kinase (AMPK) is an energy sensor that regulates energy metabolism. Roles of AMPK are related to many metabolic pathways， especially in the lipids metabolism process. The regulation roles of AMPK are played via multiple signaling pathways in skeletal muscle， liver， breast and other tissues. The study of the regulation mechanism of AMPK on lipids metabolism provides diagnosed targets to type 2 diabetes， fatty liver， obesity， cancer and other diseases， and is expected to improve production performance of dairy cows and plays a greater role.
Key words: AMPK; lipid metabolism; signaling pathway