《生命科学》 2012, 24(4): 340-345

ThPOK在T细胞分化发育中的作用

索珊珊，张　伟，汪　洌^﹡

(浙江大学医学院免疫学研究所，杭州 310058)

摘　要：摘　要：ThPOK (T-helper-inducing POZ/Krueppel-like factor)又被称为Zbtb7b、Zfp67、cKrox，隶属于一个很大的转录因子家族——POK家族。ThPOK最初是被认为与Ⅰ型胶原蛋白基因的转录抑制有关，但近年来的研究发现，ThPOK在T细胞分化过程中至关重要，特别是对CD4+T细胞的分化发育起着命运决定的核心作用。该文综述了ThPOK在CD4+T细胞分化过程中的作用特点及其与另外两种重要转录因子GATA3和Runx3的相互作用关系，并在此基础上阐述了ThPOK在其他T细胞，如iNKT细胞、γδT细胞及效应CD8+T细胞中的作用功能。
关键词：ThPOK；CD4+T细胞；CD8+T细胞；GATA3；Runx3；iNKT细胞；γδT细胞

The role of ThPOK in T cell differentiation and development

SUO Shan-Shan， ZHANG Wei， WANG Lie^﹡

(Institute of Immunology， Zhejiang University School of Medcine， Hangzhou 310058， China)

Abstract: Abstract: ThPOK (T-helper-inducing POZ/Krueppel-like factor) is also called Zbtb7b， Zfp67 or cKrox， which is a member of the transcriptional repressor family of POK(POZ and Kruppel). ThPOK was originally cloned as a negative regulator of collagen gene promoters， while new results indicate that ThPOK plays a central role in T cell development and differentiation， especially in the specification of CD4+ T cell lineage fate. This review describes these findings and the interaction between ThPOK and the other two important transcription factors， Runx3 and GATA3. Besides， we state its expanding roles in other T cell subsets such as iNKT cells， γδT cells and CD8 +T cells.
Key words: ThPOK; CD4+T cell; CD8+T cell; GATA 3; Runx3; iNKT cell; γδT cell