《生命科学》 2012, 24(2): 181-184

人3型副流感病毒疫苗的研究进展

闫　微，井申荣^*

(昆明理工大学生命科学与技术学院，昆明 650504)

摘　要：摘　要：人3 型副流感病毒是一种主要感染人类肺部上皮细胞的副黏病毒，可引起肺炎和支气管炎，在婴幼儿和免疫力低下的成人中有较高的发病率。经过多年的研究，对人3 型副流感病毒疫苗的研究取得了重要的进展，但还没有有效的抗病毒药物和批准的疫苗上市。目前研究主要集中在减毒活疫苗及亚单位疫苗等，对人3 型副流感病毒当前疫苗的研究情况做简要的综述。
关键词：人3 型副流感病毒；疫苗；减毒活疫苗

An overview of human parainfluenza virus type 3 vaccine

YAN Wei， JING Shen-Rong^*

(Faculty of Life Science and Biotechnology， Kunming University of Science and Technology， Kunming 650504， China)

Abstract: Abstract: Human parainfluenza virus type 3 (HPIV3) is a respiratory paramyxovirus that infects lung epithelial cells to cause bronchiolitis and pneumonia， and it is also the cause of high morbidity among infant and the immunocompromised elderly people. Although the HPIV3 vaccine research has made important progress after many years of research， no effective antiviral therapy and licensed vaccines exist for HPIV3. Currently， several vaccine development strategies are being explored including live attenuated vaccines and subunit vaccines， etc. This review presented the current vaccine development of human parainfluenza virus type 3.
Key words: human parainfluenza virus type 3; vaccine; live attenuated vaccines