《生命科学》 2012, 24(2): 174-180

表位疫苗的设计及应用研究进展

赵　德¹，冯　磊¹，张　强²，郭建宏²，高凤山^1，2*

(1 大连大学生命科学与技术学院，分子免疫学实验室，大连 116622；2 中国农业科学院兰州兽医研究所，家畜疫病病原微生物国家重点实验室，兰州 730046)

摘　要：摘　要：表位疫苗相对传统疫苗拥有较多优势，其最大的优点就是可以克服传统疫苗造成的毒力恢复或散毒的可能。另外表位疫苗本身无毒、稳定，符合未来疫苗发展的方向。表位疫苗的设计需要从表位的筛选、优化及表位的组合等多方面展开。现对表位疫苗的设计策略及应用作一介绍。
关键词：表位疫苗；筛选; 优化；抗原

Design and application of epitope-vaccines

Zhao De¹， Feng Lei¹， Zhang Qiang²， Guo Jian-Hong²， Gao Feng-Shan^1，2*

(1 Laboratory of Molecular Immunology， College of Life Science and Technology， Dalian University， Dalian 116622， China; 2 Veterinary Research Institute， Chinese Academy of Agricultural Sciences， Lanzhou 730046， China)

Abstract: Abstract: Comparing to traditional vaccines， epitope-vaccine displays many advantages. The most outstanding advantage for epitope-vaccine is that it can avoid the disadvantages of virus-excretion and virulence recovery. In addition， the epitope-vaccine is atoxic and stable. Therefore， the epitope-vaccine meets to the developing direction of future vaccine. Design of epitope-vaccine needs to carry out from epitope-screening， optimization and assemblage of epitopes， etc. Presently， we will give an introduction to designing strategy and application of epitopevaccine.
Key words: epitope-vaccine; screening; optimization; antigen