《生命科学》 2012, 24(2): 156-160

PPARs调控巨噬细胞的活化与功能

崔立宝，唐朝克^*

(南华大学心血管病研究所，动脉硬化湖南省重点实验室，生命科学研究中心，衡阳 421001)

摘　要：摘　要：巨噬细胞是先天性防御病原体的关键组分，它参与炎症的发生和消退，同时也参与了组织的修复。巨噬细胞的多种功能通过不同的活化状态完成，即从经典活化状态到替代性活化状态，再到失活状态。巨噬细胞活化的失调与代谢、炎症和免疫病变有关，调节蛋白控制巨噬细胞的活化可作为新的治疗靶点。主要综述过氧化物酶体增殖物激活受体(PPARs) 调控巨噬细胞活化的作用。
关键词：炎症；PPARs ；替代性活化的巨噬细胞；动脉粥样硬化；糖尿病

Control of macrophage activation and function by PPARs

CUI Li-Bao， TANG Chao-Ke^*

(Institute of Cardiovascular Research， Key Laboratory for Atherosclerology of Hunan Province， Life Science Research Center， University of South China， Hengyang 421001， China)

Abstract: Abstract: Macrophage， a key component of the innate defense against pathogens， participates in the initiation and resolution of inflammation， and in the maintenance of tissues. These diverse functions of macrophages are executed via distinct activation states， ranging from classical to alternative to deactivation. The dysregulation of macrophage activation is pathogenically linked to various metabolic， inflammatory and immune disorders. Regulatory proteins controlling macrophage activation have emerged as important new therapeutic targets. Here， the mechanisms by which peroxisome proliferator-activated receptors (PPARs) transcriptionally regulate macrophage activation in disease states are reviewed.
Key words: inflammation; PPARs; alternatively activated macrophage; atherosclerosis; diabetes