《生命科学》 2012, 24(2): 139-144

肝型脂肪酸结合蛋白研究进展

王南南，徐力致^*，王亚平

(南京大学医学院遗传教研室，江苏省医学分子技术重点实验室，南京 210093)

摘　要：摘　要：肝型脂肪酸结合蛋白(liver fatty acid binding protein，L-FABP) 是脂肪酸结合蛋白(fatty acid binding proteins，FABPs) 家族重要的成员，在肝脏、小肠、肾脏等组织中均有表达。L-FABP 在不饱和脂肪酸、饱和脂肪酸、胆固醇、胆汁酸等转运过程中扮演重要角色。目前研究显示L-FABP 在脂肪肝、肝硬化以及肝癌发生发展中起到重要作用，并有望作为肝损伤的早期检测指标。此外，新近研究发现尿中L-FABP 水平还可以用于预测1 型糖尿病患者的临床结局。在2 型糖尿病中，尿中L-FABP 与糖尿病性肾病的病程有密切关系。主要就L-FABP 的特性、结构及其与疾病的关系做一综述。
关键词：肝型脂肪酸结合蛋白；脂肪酸；转运；脂肪肝；糖尿病

Progress in liver type fatty acid binding protein

WANG Nan-Nan， XU Li-Zhi^*， WANG Ya-Ping

(Jiangsu Key Laboratory of Molecular Medicine， Medical School， Nanjing University， Nanjing 210093， China)

Abstract: Abstract: Liver fatty acid binding protein (L-FABP) which mainly expresses in liver， intestine and kidney， is an important member of FABP family. It is found that L-FABP is related to the translocation of saturated fatty acid， unsaturated fatty acid， cholesterol， bile acid and so on. Many studies have indicated that L-FABP was involved in fatty liver， cirrhosis and hepatocarcinoma. Moreover， L-FABP can be an appropriate biomarker in predicting the progression of liver injury. Recent researches have demonstrated that u-LFABP might be a new tool in the prediction of diabetic nephropathy in type 1 diabetic patients. Besides， L-FABP levels reflect the severity of diabetic nephropathy accurately in type 2 diabetes. This article aims to review the characteristics， conformation of L-FABP， and its relationship with some diseases.
Key words: liver fatty acid binding protein; fatty acid; transport; liver fatty; diabetes