摘 要：摘 要：紧密连接(tight junction, TJ)是脊椎动物细胞间连接的一种主要形式，对介导上皮细胞间的黏合、维持上皮细胞的功能具有重要作用。TJ是由一系列跨膜蛋白和外周蛋白相互作用而形成的一个复杂的蛋白质体系，封闭蛋白(occludin)是构成TJ的主要成分之一。目前，已发现封闭蛋白与许多人类疾病有关。本文仅就封闭蛋白的结构、功能及其与人类疾病的关系做一综述。
关键词：封闭蛋白：紧密连接；疾病
Abstract: Abstract: The tight junction(TJ)is the most apical component of the junctional complexes of the adjacent cells in vertebrate. It acts as a multifunctional complex that is involved in regulating numerous and diverse cell functions. A group of integral membrane proteins and an array of plaque proteins have been identified. Occludin was characterized as the first integral membrane protein localized at tight junctions. Disruption of occludin expression, integrity and localization is a vital aspect of a number of diseases. Here, we present a review of the relatively newer understanding of the structure and function of occludin, as well as its role in some diseases.
Key words: occludin; tight junction; disease
