《生命科学》 2012, 24(1): 63-68

COX-2与糖尿病并发症关系研究进展

张一弛，牟艳玲，解砚英^*

(山东省医学科学院药物研究所，山东省罕少见病重点实验室，济南 250062)

摘　要：摘　要：糖尿病是一种慢性、低度炎症性疾病。多种因素刺激下，环氧化酶COX-2在胰岛及多种组织中高水平表达。它通过与炎症因子和炎症介质，如一氧化氮、核因子-κB、前列腺素E等相互作用，对相应组织产生作用，从而促进了糖尿病并发症的发生和发展。对COX-2的研究可进一步揭示糖尿病并发症发生的分子机制，为预防和治疗糖尿病并发症提供新的思路。
关键词：COX-2；糖尿病；糖尿病并发症；炎症反应

Research progress in relations between cyclooxygenase 2 and diabetes mellitus complications

ZHANG Yi-Chi， MOU Yan-Ling， XIE Yan-Ying^*

(Key Laboratory for Rare Disease of Shandong Province， Depantment of Pharmacology， Institute of Materia Medica， Shandong Academy of Medical Sciences， Jinan 250062， China)

Abstract: Abstract: Recently， diabetes mellitus is viewed as a chronic and low level inflammation disease. Stimulated by several factors， cyclooxygenase-2 (COX-2) is over expressed in pancreatic cells and other tissues. Interacting with some inflammatory factors and inflammatory mediators， such as nitric oxide， nuclear factor-κB， and prostaglandin E， it can produce the effects on corresponding tissues. COX-2 plays a crucial role in the pathogenesis and progress of diabetic complications. Further researches of COX-2 will be helpful in revealing the molecular mechanisms of diabetes complications， and will provide us a new way to prevent and treat diabetes mellitus.
Key words: COX-2; diabetes mellitus; diabetic complications; inflammation