《生命科学》 2012, 24(1): 54-57

促炎症消退新介质：消退素与保护素

袁红梅¹，万敬员¹，张　力^2*

(1 重庆医科大学药理学教研室，重庆 400016；2 重庆医科大学病理生理学教研室，重庆 400016)

摘　要：摘　要：炎症启动(initiation)、发展之后的消退(resolution)是受到体内促消退介质(pro-resolving mediator)调控的主动过程。继发现由花生四烯酸衍生的脂氧素(lipoxin)后，新近又从炎症消退阶段的炎性渗出物中分离出由ω-3多不饱和脂肪酸转化而来的消退素(resolvin)与保护素(protectin)，它们也具有强效的抗炎促消退效应，成为促炎症消退介质的新成员。
关键词：消退素；保护素；炎症；炎症消退；不饱和脂肪酸

Novel pro-resolving mediators: resolvin and protectin

YUAN Hong-Mei¹， WAN Jing-Yuan¹， ZHANG Li^2*

(1 Department of Pharmacology， Chongqing Medical University， Chongqing 400016， China; 2 Department of Pathophysiology， Chongqing Medical University， Chongqing 400016， China)

Abstract: Abstract: The resolution phase of inflammation， subsequent to its initiation and development phase， is an active process regulated by endogenous pro-resolving mediators. Following the discovery of lipoxin derived from arachidonic acid， the ω-3 polyunsaturated fatty acids (PUFAs)-derived resolvin and protectin were recently identified from the inflammatory exudates during the spontaneously resolution phase of inflammation. They are new members of pro-resolving mediator family with potent anti-inflammatory and pro-resolving effects.
Key words: resolvin; protectin; inflammation; inflammation resolution; polyunsaturated fatty acids