《生命科学》 2012, 24(1): 43-49

肠道病毒71型的功能基因组学研究进展

高　爽，龙健儿^*

(复旦大学上海医学院病原生物学系，上海 200032)

摘　要：摘　要：肠道病毒71型(enterovirus type 71， EV71)感染通常引起婴幼儿手足口病(hand， foot and mouth disease， HFMD)，但少数可引起无菌性脑膜炎(asepic meningitis)、脑炎(encephalitis)和类脊髓灰质炎的麻痹性疾病(poliomyelitis-like paralysis)等严重的神经系统疾病。功能基因组学研究对于探讨EV71的感染及复制过程、药物及疫苗的研制具有重大意义。该文就EV71的基因组结构及其功能的研究进展作简要的概述。
关键词：EV71；病毒复制；基因组功能

Progress in the functional genomics researches on human enterovirus 71

GAO Shuang， LONG Jian-Er^*

(Department of Medical Microbiology and Parasitology， Shanghai Medical College of Fudan University， Shanghai 200032， China)

Abstract: Abstract: Enterovirus 71 (EV71) is the main causative agent of hand， foot and mouth disease (HFMD) in infant， also has been associated with neurological diseases including asepic meningitis， brain stem encephalitis and poliomyelitis-like paralysis. Here we focus on the progress in the research on EV71 genomic structure and function. Knowledge on EV71 functional genomics would be great helpful to development of antiviral drugs and vaccines.
Key words: EV71; virus replication; functional genomics