《生命科学》 2011, 23(12): 1283-1291

经典WNT信号通路与哺乳动物肺器官发育

施珏平，滕鸿琦，肖爱平，李小兵，张明凤^*

(福建师范大学生命科学学院，福建省发育与神经生物学重点实验室，福州 350108)

摘　要：摘　要：肺器官发育是上皮和间充质相互作用的过程，由多条信号通路共同调控。已知经典WNT 信号通路对细胞的增殖、凋亡和分化起着重要的调控作用，在小鼠等模式生物上研究发现，它也参与了哺乳动物肺器官发育的调控过程。综述近年来经典WNT 信号通路成员在哺乳动物肺器官发育过程中的表达变化、作用功能及表达异常可能诱发的肺部疾病，以期为研究经典WNT 信号通路调控人类肺器官发育的分子机制及相关肺部疾病的诊治奠定基础。
关键词：肺；器官发育；WNT 信号通路；β-catenin
中图分类号：Q954.57; Q2 文献标志码：A

Canonical WNT signaling pathway and mammalian lung development

SHI Jue-Ping， TENG Hong-Qi， XIAO Ai-Ping， LI Xiao-Bing， ZHANG Ming-Feng*

(Fujian Key Laboratory of Developmental and Neuro Biology， College of Life Sciences， Fujian Normal University，Fuzhou 350108， China)

Abstract:

Abstract: Lung development is a consequence of interaction between epithelium and mesenchyme， which is regulated by several signaling pathways. It is well known that the canonical WNT signal pathway plays an important role in the regulation of cell proliferation， apoptosis and differentiation. Recent studies on model organisms， such as mouse and rat， verified that the canonical WNT signal pathway participated in the regulation of mammalian lung development. This review has summarized the main recent research findings on the role of canonical WNT signaling components in the regulation of mammalian lung development. The gene expression and function in all members of canonical WNT signaling pathway， and the possible lung diseases induced by abnormal expression of canonical
WNT signaling components during the mammalian lung development were emphasized to state. This review will provide valuable information for further illustration of the molecular mechanisms of WNT signals in the regulation
of human lung development， as well as will be in favor of finding the way to diagnose and cure human lung diseases.

    

Keywords: lung; organ development; WNT signaling pathway; β-catenin