《生命科学》 2011, 23(12): 1147-1161

天然免疫模式识别受体与树突状细胞的发现和意义

钟波¹ 舒红兵^2*

(1 美国德克萨斯大学安德森癌症中心免疫学系；2 武汉大学生命科学学院，武汉 430072)

摘　要：

摘　要：2011 年的诺贝尔生理学或医学奖授予了Bruce A. Beutler，Jules A. Hoffmann 以及Ralph M. Steinman教授，以奖励他们在天然免疫模式识别受体和树突状细胞研究领域所做出的开创性贡献。宿主的天然免疫系统依赖模式识别受体识别入侵的病原微生物，并通过树突状细胞对其加工处理将抗原提呈给T 细胞，从而激活适应性免疫。回顾模式识别受体和树突状细胞发现的过程，介绍该领域最近的研究进展，并对它们在疾病预防和治疗中的应用进行了讨论。

    

关键词：模式识别受体；树突状细胞；信号转导；疾病
中图分类号：R392.1 文献标志码：A

Discovery and significance of pattern-recognition receptors and dendritic cells

ZHONG Bo¹， SHU Hong-Bing^2*

(1 Department of Immunology and Center for Inflammation and Cancer， the University of Texas MD Anderson Cancer Center; 2 College of Life Science， Wuhan University， Wuhan 430072， China)

Abstract:

Abstract: The Nobel Prize in Physiology or Medicine in 2011 was awarded to Bruce A. Beutler and Jules A. Hoffmann for their discoveries of the pattern-recognition receptors (PRRs) in innate immunity， and Ralph M. Steinman for his discovery of the dendritic cells (DCs) and their roles in adaptive immunity. Host recognizes invading pathogens through PRRs in innate immunity， and pathogen-associated peptides processed by DCs are presented to the T cells to activate adaptive immunity. This review will summarize the history for the discoveries of PRRs and DCs， introduce the latest advances and discuss their applications in the treatment of related diseases.

    

 Key words: pattern-recognition receptor; dendritic cell; signaling transduction; disease