《生命科学》 2011, 23(11): 1101-1105

硬脂酰辅酶A去饱和酶与脂代谢调控

彭　恭^1，2*，杜雅兰³，徐式孟¹，刘平生¹

(1 中国科学院生物物理研究所，生物大分子国家重点实验室，北京 100101；2 吉林大学第一医院，长春 130021；3 南华大学医学院，组织胚胎学教研室，衡阳 421001)

摘　要：摘　要：硬脂酰辅酶A 去饱和酶(stearoyl-coenzyme A desaturase， SCD) 是催化饱和脂酰辅酶A 生成单不饱和脂酰辅酶A 的关键酶，在不同的组织中有多种亚型分布。高热量饮食、运动、激素等因素均影响SCD的基因表达水平。对SCD 蛋白表达水平和活性的调控会直接影响生物体内饱和脂肪酸 (saturated fatty acid， SFA) 与单不饱和脂肪酸 (monounsaturated fatty acid， MUFA) 的比例，从而进一步影响整个机体的脂质代谢，进而与细胞应激反应及胰岛素敏感性直接相关。因此，SCD 逐渐成为代谢疾病治疗的一个潜在的靶分子。
关键词：硬脂酰辅酶A 去饱和酶；脂质代谢；细胞应激反应；胰岛素敏感性

Stearoyl-CoA desaturase-1 and lipid metabolism

PENG Gong^1，2*， DU Ya-Lan³， XU Shi-Meng¹， LIU Ping-Sheng¹

(1 National Laboratory of Biomacromolecules， Institute of Biophysics， Chinese Academy of Sciences， Beijing 100101，China; 2 The First Hospital， Jilin University， Changchun 130021， China; 3 Department of Histology and Embryology，University of South China， Hengyang 421001， China)

Abstract: Abstract: Stearoyl-CoA desaturase (SCD) is a key enzyme that catalyzes the saturated fatty acyl-CoAs to unsaturated fatty acyl-CoAs and several SCD isoforms were found in different tissues and organisms. SCD mRNA expression level can be regulated by many factors， such as high calorie diet， excise， and hormones. Regulation of expression and activity of SCD can alter the ratio of monosaturaed fatty acid (MUFA) to saturated fatty acid (SFA)， which can regulate lipid metabolism and further affect cellular stress response and insulin sensitivity. Taken together， accumulated evidence suggests that SCD could be a therapeutic target of metabolic syndrome.
Key words: stearoyl-CoA desaturase-1; lipid metabolism; cellular stress response; insulin sensitivity