《生命科学》 2011, 23(11): 1057-1062

调控型分泌的分子机制研究进展

杨　松¹，徐　涛^1，2*

(1 华中科技大学生命科学与技术学院，武汉 430074；2 中国科学院生物物理研究所，北京 100101)

摘　要：摘　要：调控型分泌途径对于维持内分泌细胞和神经元的功能非常重要。内分泌和神经系统的细胞将神经递质、神经肽和激素等包装在分泌囊泡内，然后在受到刺激时将这些物质释放到细胞外。调控型分泌囊泡，从生成、转运到与细胞膜的融合都需要许多蛋白质的参与和调节。简要总结参与这些过程的一些重要蛋白质的研究进展。
关键词：分泌；囊泡；生成；转运；激素；神经肽

Progress in studying the molecular mechanism of regulated exocytosis

YANG Song¹， XU Tao^1，2*

(1 College of Life Science and Technology， Huazhong University of Science and Technology ，Wuhan 430074， China; 2 Institute of Biophysics， Chinese Academy of Sciences， Beijing 100101， China)

Abstract: Abstract: Regulated secretory pathway is important for the function of endocrine cells and neurons. Cells in the endocrine and nervous systems package neurotransmitters， neuropeptides and hormones into secretory vesicles for release in a regulated manner upon stimulation. The biogenesis， translocation and fusion of regulated secretory vesicles require the regulation and participation of many proteins. In this article， research progress of some key factors has been reviewed.
Key words: secretion; vesicle; biogenesis; translocation; hormones; neuropeptides