《生命科学》 2007, 19(2):

热激蛋白对细胞凋亡的调节作用

秦 佳¹，杨金莹²，伊淑莹¹，刘 箭^1*

1山东师范大学生命科学学院，济南 250014；2中国石油大学(华东)生物工程与技术中心，青岛 266555

摘　要：摘　要：细胞凋亡是生物发育过程中或在正常生理状态下清除衰老及受损细胞的一种普遍现象。细胞凋亡的发生受胞外或胞内的多种刺激源所诱导，其中热激蛋白是细胞凋亡的调控因子之一。本文着重讨论了热激蛋白在细胞凋亡调节中所发挥的作用。
关键词：细胞凋亡；热激蛋白；caspase

Heat shock proteins in the regulation of apoptosis

QIN Jia¹, YANG Jinying², YI Shuying¹, LIU Jian^1*

1 College of Life Sciences, Shandong Normal University, Jinan 250014, China; 2 Center for Bioengineering and Biotechnology of UPC, Qingdao 266555, China

Abstract: Abstract: Apoptosis is a common phenomenon in developmental processes or in normal physiological conditions, where the old or damaged cells have to be eliminated. Apoptosis is induced by an array of extra- or intracellular stimuli and regulated by a variety of proteins including the heat shock proteins (HSPs). The present discussion is focused on the functions of HSPs in the regulation of apoptosis.
Key words:  apoptosis; HSPs; caspase