《生命科学》 2011, 23(10): 1009-1013

钙网蛋白与肿瘤免疫

吴红艳，王艳林^*

(三峡大学分子生物学研究所，宜昌 443002；武汉大学中南医院肿瘤科，武汉 430072)

摘　要：


摘　要：钙网蛋白是内质网分子伴侣，负责糖蛋白的折叠及维持细胞内Ca2+ 平衡。新近研究发现，某些凋亡刺激能诱导肿瘤细胞内的钙网蛋白快速转位到肿瘤细胞膜上，这种表面包被有大量钙网蛋白的肿瘤细胞，能被抗原呈递细胞有效识别和吞噬，由此激发抗同种肿瘤的特异性免疫杀伤效应，提示钙网蛋白在肿瘤免疫治疗中的潜在应用价值。对钙网蛋白在肿瘤免疫中的研究进展作一综述。
关键词：钙网蛋白；内质网应激；免疫原性细胞死亡；肿瘤免疫
中图分类号：R730.51 文献标识码：A

Calreticulin and tumor immunity

WU Hong-Yan， WANG Yan-Lin^*

(Institute of Molecular Biology， Three Gorges University， Yichang 443002， China;Department of Oncology， Zhongnan Hospital， Wuhan University， Wuhan 430072，China)

Abstract: Abstract: Calreticulin (CRT) is an endoplasmic reticulum (ER) chaperone responsible for glycoprotein folding and Ca2+ homeostasis. Recent researches showed that some apoptotic stimulus could trigger relocation of intracellular CRT onto the tumor cell surfaces. These CRT-coated tumor cells could be recognized and phagocytosed by antigen presenting cells efficiently， and elicited specific anti-tumor immune response against homologous tumor cells， indicating the potential value of CRT in tumor immune therapy. Here， we summarize the research progress of CRT
in tumor immunity.
Key words: calreticulin; endoplasmic reticulum stress; immunogenic cell death; tumor immunity