《生命科学》 2011, 23(10): 963-968

乳腺癌干细胞分子特性及其治疗新策略

何大健¹，吴长清¹，黄云超²，杨世华^1*

(1 昆明理工大学生命科学与技术学院衰老与肿瘤分子遗传学实验室，昆明 650224；2 昆明医学院第三附属医院暨云南省肿瘤医院胸外科，昆明 650118)

摘　要：
摘　要：乳腺癌是一种严重影响女性健康甚至危及生命的疾病。环境、饮食习惯、疾病等均有可能诱发人类乳腺细胞癌基因活化或抑癌基因失活，其诱发过程可通过细胞、动物模型所证实。最新研究指出，乳腺癌肿瘤干细胞的分子特性研究为乳腺癌发生、发展的认识提供了重要的佐证。另外，MicroRNAs 在乳腺癌中表现促进或抑制瘤细胞生长与分化。这些研究的深入开展将为乳腺癌的防治提供新思路。
关键词：乳腺癌；ER ；肿瘤干细胞；miRNA ；分子标记
中图分类号：R737.9 文献标志码：A

The research of molecular characteristics of breast cancer stem cells and its new therapeutic strategies

HE Da-Jian¹， WU Chang-Qing¹， HUANG Yun-Chao²， Yang Shi-Hua^1*

(1 Laboratory of Molecular Genetics of Aging and Tumor， Faculty of Life Science and Technology， Kunming University of Science and Technology， Kunming 650224， China; 2 Department of Thoracic Surgery， the 3rd Affiliated Hospital of Kunming Medical University， Yunnan Provincial Tumor Hospital， Kunming 650118， China)

Abstract:
Abstract: Breast cancer affects women’s health seriously and even be life-threatening. Many factors can trigger cancer gene activation or tumor-suppressor gene inactivation in human breast cells， these factors include environment， dietary habits， disease， etc. The induction of neoplastic transformation has been confirmed by cell and animal models. The updated studies point out that the molecular characteristics of breast cancer stem cells provide an important evidence for understanding tumorogenesis and development. In addition， microRNA respectively plays important roles in enhancing or suppressing growth and differentiation of breast cancer. The in-depth research will provide new ideas in the prevention and control of the breast cancer.
Key words: breast cancer; ER; cancer stem cell; miRNA; molecular marker