《生命科学》 2011, 23(9): 917-920

合成噬菌体的贡献与风险

赵向娜，杨瑞馥^*

(军事医学科学院微生物流行病研究所，病原微生物生物安全国家重点实验室，北京 100071)

摘　要：摘　要：噬菌体(bacteriophage， phage)是感染细菌、真菌、放线菌或螺旋体等微生物的细菌病毒的总称。噬菌体在生态、微生物进化、细菌性疾病预防和治疗、细菌鉴定与疾病诊断等方面扮演重要角色。基因组测序技术和高效合成平台促进了合成基因组学的发展。利用合成基因组学技术，对噬菌体基因组进行设计或者合成出新的噬菌体来服务人类在不久的未来可能成为现实。但与此同时，合成噬菌体带来的风险也必须认真考虑。
关键词：噬菌体；合成基因组学；细菌性疾病

Contribution and risk of synthetic bacteriophage

ZHAO Xiang-Na， YANG Rui-Fu^*

(State Key Laboratory of Pathogen and Biosecurity， Institute of Microbiology and Epidemiology， Chinese Academy of Military Medical Sciences， Beijing 100071， China)

Abstract: Abstract: Phages are viruses， which infect bacteria， fungi， actinomycetes， spiral bacteria and other microorganisms. Phages play an important role in ecology， microbial evolution， prevention and treatment of bacterial diseases， bacterial identification and disease diagnosis etc. Genome sequencing technology and efficient synthesis platform promote the development of synthetic genomics. Designing phage genomes or synthetizing novel phages to serve human with synthetic genomics technology could become a reality in the near future. Meanwhile， risks brought by synthetic phage must be considered seriously.
Key words: phage; synthetic genomics; bacterial diseases