《生命科学》 2011, 23(9): 900-911

合成生物学与天然产物开发

卢志国^1，2，汪建峰^1，2，蒙海林¹，熊智强¹，王　勇^1*

(1中国科学院上海生命科学研究院植物生理生态研究所合成生物学重点实验室，上海 200032；2华东理工大学生物反应器工程国家重点实验室，上海 200237)

摘　要：摘　要：天然产物依然是临床用药的重要来源。合成生物学的诞生为天然产物的开发提供了全新的机遇，传统的微生物药物、植物天然产物等研究领域都因合成生物学而获得新生。重点介绍了合成生物学在天然产物开发中的应用，包括新化合物及其生物合成元件的筛选，基于理性设计的天然产物异源生物合成，人工底盘细胞的系统优化等。
关键词：合成生物学；天然产物；异源生物合成

Synthetic biology and natural products development

LU Zhi-Guo^1，2， WANG Jian-Feng^1，2， MENG Hai-Lin¹， XIONG Zhi-Qiang¹， WANG Yong^1*

(1 Key Laboratory of Synthetic Biology， Institute of Plant Physiology & Ecology， Shanghai Institutes for Biological Sciences， Chinese Academy of Sciences， Shanghai 200032， China; 2 State Key Laboratory of Bioreactor Engineering， East China University of Science and Technology，Shanghai 200237， China)

Abstract: Abstract: Natural products (NPs) traditionally have played an important role in drug discovery and were the basis of most early medicines. The emergence of synthetic biology provides a new opportunity for the traditional natural products development. Natural products development and manufacturing based on the concept of synthetic biology will attract more and more attentions. This article reviews the application of synthetic biology in natural products development and manufacturing， including novel compounds discovery， biosynthetic elements screening， rational-design-based natural products biosynthesis， natural products biosynthesis and optimization in the heterologous artificial chassis cells. 
Key words: synthetic biology; natural product; heterologous biosynthesis