《生命科学》 2011, 23(9): 875-881

利用合成生物学生产药物和燃料

王　猛，赵惠民^*

(Department of Chemical and Biomolecular Engineering， University of Illinois at Urbana-Champaign， Urbana， IL 61801，USA

摘　要：摘　要：合成生物学是一个快速发展的研究领域，其重要性体现在科学研究和应用开发两方面。它不但加深了我们对复杂的生物过程与机理的理解， 而且使得基础生物研究向实际应用的快速转化成为可能。 将介绍一些新型高效的合成生物学工具以及如何利用它们开发能从可再生原料生产药物和燃料的工程菌株。
关键词：合成生物学; 生物燃料; 代谢工程; 蛋白质工程; 基因调控

Microbial synthesis of drugs and fuels via synthetic biology

WANG Meng， ZHAO Hui-Min^*

(Department of Chemical and Biomolecular Engineering， University of Illinois at Urbana-Champaign， Urbana， IL 61801，USA)

Abstract: Abstract: Synthetic biology is a rapidly growing research field of scientific and practical importance.  It not only deepens our understanding of complex biological processes and mechanisms but also enables the rapid translation of fundamental biological research to practical applications. In this review， we will describe a few novel and highly efficient synthetic biology tools and their applications in the development of recombinant organisms capable of producing drugs and fuels from renewable feedstock.
Key words: synthetic biology;  biofuel;  metabolic engineering; protein engineering; gene regulation