《生命科学》 2011, 23(8): 773-778

PLMT家族成员SET7/9的非组蛋白甲基化作用

高丽丽，余卫平^*

(东南大学医学院病理学与病理生理学系，南京 210009)

摘　要：摘　要：SET7/9是蛋白赖氨酸甲基化转移酶(protein lysine methyltransferases， PLMTs或PKMTs)家族成员，具有SET结构域。现已发现SET7/9是一种赖氨酸单甲基化转移酶，除了能使组蛋白H3第四位赖氨酸(lysine 4 of histone 3， H3K4)单甲基化外，更重要的能使一些转录因子、肿瘤抑制因子、膜相关受体等非组蛋白单甲基化，其甲基化作用主要与蛋白稳定和转录活化有关。该效应受赖氨酸特异性去甲基酶1(lysine specifc demethylase， LSD1)的抑制。SET7/9与LSD1两者效应的平衡对维持体内活性蛋白质含量、调节基因表达具有重要意义。
关键词：SET7/9；赖氨酸甲基化转移酶；非组蛋白；甲基化作用

Methylation of non-histone proteins by SET7/9， a member of PLMT family

GAO Li-Li， YU Wei-Ping^*

(Department of Pathology and Pathophysiology， College of Medicine， Southeast University， Nanjing 210009， China)

Abstract: Abstract: SET7/9 is a member of protein lysine methyltransferase family. It contains a SET domain. Recent studies demonstrate that SET7/9 methylates both lysine 4 of histone 3 (H3-K4) and lysine(s) of non-histone proteins including transcription factors， tumor suppressor and membrane-associated receptors，so on. SET7/9 is exclusively a monomethyltransferase， and it is mainly related to protein stabilization and transcriptional activation. Additionally， mathylation by SET7/9 can be blocked by lysine specifc demethylase 1(LSD1). Thus， the equilibrium of effects between SET7/9 and LSD1 is important to maintain the content of some active proteins and to regulate the expression of some genes.
Key word: SET7/9; lysine methyltransferase; non-histone protein; methylation