《生命科学》 2011, 23(8): 762-766

甲状腺转录因子NKx2.1的疾病研究进展

程　璐^1*，王　波²

(1 中山大学东校区教学实验中心，广州 510006；2 中山大学中山医学院生物教研室，广州 510080)

摘　要：摘　要：甲状腺转录因子-1(TITF-1/NKx2.1)是甲状腺组织特异性转录因子的家族成员之一，其表达和缺失与许多人类疾病关系密切。许多的学者试图从与Nkx2.1基因相关的疾病研究出发，探讨它在基因治疗和基因诊断中所起的作用。将对其中较新的成果作一综述，并对今后的研究方向作一展望。
关键词：甲状腺转录因子-1；NKx2.1；疾病；肿瘤；神经

The advances on thyroid transcription factor-1 in disease research

CHENG Lu^1*， WANG Bo²

(1 Laboratory Center of East Campus， Sun Yat-Sen University， Guangzhou 510006， China; 2 Department of Biology， Zhongshan School of Medicine， Sun Yat-Sen University， Guangzhou 510080， China)

Abstract: Abstract: Thyroid transcription factor-1(TITF-1/NKx2.1) is one of the NKx2 tissue-specific transcription factor family members， of which expression and deletion are closely related with many human diseases. Starting from the research of disease associated with NKx2.1 genes， more and more domestic and overseas scholars are trying to discuss what roles it played in the process of genetic therapy and genetic diagnosis. In this article， the current research outcome was summarized and the future development direction in this field was prospected.
Key words: TITF-1; NKx2.1; disease; tumor; neuron