《生命科学》 2011, 23(8): 736-741

HLA-G诱导DC细胞在免疫耐受机制中的研究进展

许惠惠，阮嫣赟，颜卫华，林爱芬^*

(温州医学院附属浙江省台州医院中心实验室，临海 317000)

摘　要：摘　要：树突状细胞(dendritic cells， DC)是体内最重要的专职抗原递呈细胞，具有刺激初始型T细胞增殖，启动机体免疫反应并决定免疫应答方向的功能。人白细胞抗原-G(human leukocyte antigen -G， HLA-G)属于非经典的HLA-I类分子，能够调控DC的细胞表型和细胞因子表达谱，诱导DC获得致免疫耐受功能。耐受型DC呈现未成熟或半成熟样，释放IL-10等抑制性细胞因子和表达免疫球蛋白样转录受体4(immunoglobulin-like transcript 4， ILT4)等HLA-G受体，继而诱导产生调节性T细胞(regulatory T cells， Treg)。对HLA-G诱导产生耐受型DC细胞及其免疫学功能作一综述。
关键词：HLA-G；树突状细胞；免疫耐受

Recent progress of HLA-G-modified DC cells in tolerogenic immune mechanism

XU Hui-Hui， RUAN Yan-Yun， YAN Wei-Hua， LIN Ai-Fen^*

(Laboratory Center， Wenzhou Medical College Affiliated Taizhou Hospital of Zhejiang Province， Linhai 317000， China)

Abstract: Abstract: Dendritic cells (DC) are the most important professional antigen presenting cells (APCs)， which have the functions of stimulating the proliferation of naïve T cells， initiating immune response， and inducing immunity or immunologic tolerance. Human leukocyte antigen (HLA)-G， a non-classical HLA class I molecule， is involved in the generation of tolerogenic DCs， which express high levels of immunoglobulin-like transcript (ILT)-4， secrete high amounts of IL-10， and induce allospecific regulatory T cells (Treg) in vivo and in vitro. In the present review， we discuss current findings on the functional plasticity of tolerogenic DC induced by HLA-G.
Key words: HLA-G; dendritic cell; immune tolerance