N-乙酰氨基葡萄糖转移酶(OGT)研究进展
孙 红，马晓峰，任飞飞，张连文，王 鹏*
(南开大学药学院，天津300071)
摘 要：
摘 要: O-GlcNAc是一种广泛存在于蛋白质丝/苏氨酸残基上的动态、可逆的蛋白翻译后修饰，它广泛分布在细胞浆和细胞核中，参与调节多种细胞途径。研究表明蛋白的O-GlcNAc糖基化与神经退行性疾病、糖尿病和癌症等疾病相关。在体内，O-GlcNAc动态修饰由N-乙酰氨基葡萄糖转移酶(OGT)和N-乙酰氨基葡萄糖苷酶(OGA)协同完成。近年来，OGT逐渐成为糖生物学领域的研究热点，在其结构、作用机制及晶体学方面取得了快速发展。
关键词: O-GlcNAc糖基化；N-乙酰氨基葡萄糖转移酶(OGT)；作用机制；晶体结构
中图分类号：Q55 文献标志码：A
A review on N-acetylglucosamine transferase (OGT)
SUN Hong， MA Xiao-Feng， REN Fei-Fei， ZHANG Lian-Wen， WANG Peng*
（College of Pharmacy， Nankai University， Tianjin 300071，China）
Abstract:
Abstract: N-acetylglucosamine (O-GlcNAc) modification on protein serines/threonines is a dynamic， inducible and abundant post-translational modification， which is found on numerous cytoplasm and nucleus proteins， regulating many cellular processes. It has been demonstrated that O-GlcNAc plays important roles in some human diseases， such as diabetes and neurodegenerative diseases. O-GlcNAcylation is regulated by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) in vivo. The past decades has seen a mass of research on OGT， include studies on the protein structure and the mechanism linked to many important diseases. Recently， OGT is becoming the spotlight in glyco-biological research.
Key words：O-GlcNAc modification；N-acetylglucosamine transferase (OGT)；mechanism of action；crystallography
