《生命科学》 2011, 23(6): 583-591

鞘糖脂研究进展

王艳萍，王　征，朱　健，俞云会，许秀坤，李云森^*

(苏州大学生物医学研究院，苏州 215123)

摘　要：摘　要：鞘糖脂位于细胞膜脂质双分子层，是哺乳动物细胞膜上的必需组成成分之一，参与细胞的多种生物学活动，其生物学功能非常复杂。在免疫应答、细胞发育、细胞识别及分化中都发挥重要的作用。组织器官中鞘糖脂的异常表达往往与各种疾病具有明显的相关性。因此鞘糖脂的结构表征、构效关系研究以及与之相关的鞘糖脂生物合成及分解代谢途径的研究已成为近年来的热点问题。最近研究也表明鞘糖脂在疾病的发生发展及治疗过程中都具有至关重要的作用。对鞘糖脂的结构与功能的关系、糖脂的合成代谢以及糖脂的分离分析方法作一综述。
关键词：鞘糖脂；分离分析；功能；疾病；合成代谢
中图分类号： 文献标志码：A

Progress in study of glycosphingolipids

WANG Yan-Ping， WANG Zheng， ZHU Jian， YU Yun-Hui， XU Xiu-Kun， LI Yun-Sen^*

(Institutes of Biology and Medical Sciences， Soochow University， Suzhou 215123， China)

Abstract: Abstract: Glycosphingolipids locate in the bilayer lipid membrane. They are important compositions of the membrane of mammals. Their biological function is very complex. They play important roles in the immune response， cell growth， cell recognition， differentiation， etc. The abnormal expressions of glycosphingolipids in various tissues often have obvious associations with diverse diseases. Therefore， structure characterization， QSAR studies， biosynthesis and catabolic pathways of glycosphingolipids have become hot issues in recent years. And the up-to-date studies have shown that glycosphingolipids play an crucial role in the development and treatment of diseases. The current papers about structure， function， biosynthesis and metabolism of glycosphingolipids are summarized.
Key words: glycosphingolipids; separation and characterization; function; diseases; biosynthesis and metabolism