《生命科学》 2011, 23(6): 577-582

糖基转移酶在神经系统中的作用

陶　涛，严美娟，沈爱国^*

(南通大学江苏省神经再生重点实验室，南通 226001)

摘　要：摘　要：神经系统的发育及其正常功能的维持受到精确的控制，其调控异常导致的神经系统疾病成为危害健康的重要因素。研究神经系统的发育及其疾病发生的分子机制是生命科学的热点。糖基转移酶是一组催化糖链合成及糖链与蛋白质或者脂质形成复合物的酶类。糖基转移酶可以调节神经细胞表面多种蛋白质及脂质的糖基化，参与神经系统的发生及多种疾病发病过程的调控。对糖基转移酶在神经系统发育和疾病中的作用做一综述。
关键词：糖基转移酶；神经发育；神经系统疾病
中图分类号：Q555+.4 文献标志码：A

The Function of glycosyltransferase in nervous system

TAO Tao， YAN Mei-Juan， SHEN Ai-Guo^*

(Jiangsu Key Laboratory of Neuroregeneration， Nantong University， Nantong 226001， China)

Abstract: Abstract: The development and function maintenance of the nervous system is under precise control， and its abnormal regulations always cause nervous system diseases. Therefore， much effort is made to understand the  development and pathology of the nervous system. Glycosyltransferases were discovered as a group enzymes which could catalysis the synthesis of carbohydrate chain and forming of carbohydrate-protein/lipid complex. It is reported that glycosyltransferases are involved in many biological processes， and also participates in nervous system biology. The function of the glycosyltransferases in the development and the pathology of the nervous system are summarized.
Key words: glycosyltransferase; neural development; nervous system disease