《生命科学》 2011, 23(6): 555-562

C型凝集素

谢建辉，顾建新^*

(复旦大学上海医学院，卫生部糖复合物重点实验室，上海 200032)

摘　要：摘　要：C 型凝集素(C-type lectin) 代表一个识别碳水化合物配体依赖于钙离子(Ca2+) 参与的糖原结合蛋白家族，含有一个或多个一级结构和二级结构同源的碳水化合物识别结构域。随着研究的深入，越来越多的C 型凝集素能够识别体内的非糖类的配体，包括蛋白质和脂类等。这些C 型凝集素在维持机体稳态、免疫防御以及免疫监视等重要生理病理过程中发挥着重要作用。就C 型凝集素的结构、分类和在免疫系统中的功能作一介绍。
关键词：凝集素；C 型凝集素结构域；经典C 型凝集素；非经典C 型凝集素
中图分类号：Q522 ；R730.231　　文献标志码：A

C-type lectins

XIE Jian-Hui， GU Jian-Xin^*

(Key Laboratory of Glycoconjugate Research， Ministry of Health; Shanghai Medical College， Fudan University， Shanghai，200032， China)

Abstract: Abstract: C-type lectins are Ca2+-dependent glycan-binding proteins and share primary and secondary structural homology in their carbohydrate-recognition comains (CRDs). However， many members of this family are recently identified not to bind carbohydrates and have evolved to recognize non-sugar ligands such as proteins and lipids.The large family of C-type lectins has an important role in the physiological functions and pathological processes including immune homeostasis， immune defenses， and immune surveillance and so on. In this short review， we summarize the structure of C-type lectin domain， the classification of C-type lectins and their role in the immune system.
Key words: lectin; C-type lectin domain; classical C-type lectin; nonclassical C-type lectin