《生命科学》 2011, 23(6): 541-554

丝状真菌糖生物学

金　城

(中国科学院微生物研究所真菌地衣系统学重点实验室，北京 100101)

摘　要：摘　要：蛋白质的糖基化修饰是一种保守的真核生物蛋白质翻译后修饰，存在于从酵母到人的所有真核生物中，赋予了蛋白质功能的多样性。目前对蛋白质糖基化修饰的了解主要来源于对酵母和哺乳动物细胞的研究，但单细胞真核生物或动物细胞水平的研究，很难反映糖基化修饰在多细胞真核生物的发育分化过程中的复杂功能。由于丝状真菌是多细胞真核生物，有相对简单的发育分化过程，因而是研究多细胞真核生物糖基化功能的理想模型之一，在过去10 年中，丝状真菌的糖生物学研究开始受到重视，目前的研究结果表明糖基化修饰与丝状真菌的生长、发育密切相关。
关键词：糖基化；N- 糖基化修饰；O- 糖基化修饰；GPI 修饰；生物学功能；丝状真菌
中图分类号：Q53; Q949.32 文献标志码：A

Glycobiology in filamentous fungus

JIN Cheng

(Key Laboratory of Systematic Mycology and Lichenology， Institute of Microbiology，Chinese Academy of Sciences，Beijing 100101， China)

Abstract: Abstract: Glycosylation is a conserved post-translation modification in all eukaryotes and endues protein with multiple functions. Our knowledge of glycosylation is mainly come from the investigation of yeast and mammalian cells， however， these investigations at cellular level can not tell us the complicated function of glycosylation during development of multi-cellular eukaryotes. Filamentous fungi are multi-cellular eukaryotes with a relative simple life cycle and therefore are thought to be one of ideal models for glycobiological investigation of multi-cellular eukaryotes. During last decade， glycobiology in filamentous fungi has drawn more attentions. It has been revealed that glycosylation in filamentous fungi is involved in their growth and development.
Key words: glycosylation; N-glycosylation; O-glycosylation; GPI anchoring; biological function; filamentous fungi