《生命科学》 2011, 23(5): 487-491

大蒜中有机硫化物抗肿瘤的研究进展

陈　敏，李逐波^*

(西南大学药学院，重庆 400716)

摘　要：摘　要：大蒜是一种古老的药用植物，具有广谱的抗肿瘤作用，发挥其主要抗肿瘤作用的是多种烯丙基有机硫化物。从大蒜中有机硫化物调节致癌物的代谢、抑制肿瘤细胞周期、诱导肿瘤细胞凋亡、消除自由基和抗氧化等方面，对其抗肿瘤作用机制研究进展作一综述。
关键词：大蒜；有机硫化物；抗肿瘤

Advance in antitumor of garlic vegetable-derived organosulfur compounds

CHEN Min， LI Zhu-Bo^*

(College of Pharmaceutical Sciences， Southwest University， Chongqing 400716， China)

Abstract: Abstract: Garlic is an antiquity as medicine， it was proved by epidemiological observations and laboratory studies that garlic and its constituents possessed  broad spectrum antitumor effects. But the protective effects of garlic are related to the presence of organosulfur compounds such as allyl derivatives. The antitumor mechanisms of garlic vegetable-derived organosulfur compounds mainly included， modulation of carcinogen metabolism， inhibition of cell cycle progression， induction of apoptosis， free-radical scavenging and oxidation resistance. The advances in the antitumor mechanism of garlic vegetable-derived organosulfur compounds are described in the following review.
Key words: garlic; organosulfur compounds; antitumor