《生命科学》 2011, 23(5): 454-458

线粒体转录因子A的研究进展

姚鹏程，张　佐，彭淑红^*，周　军

(江西中医学院，南昌 330004)

摘　要：
摘　要：线粒体转录因子A(mitochondrial transcription factor A，TFAM)是参与线粒体DNA转录激活和调节线粒体DNA拷贝数的重要因子。TFAM由核基因编码，并被转入线粒体内发挥调节作用。除了转录激活作用外，TFAM还参与维持线粒体DNA(mitochondrial DNA， mtDNA)的拷贝数，改善线粒体功能以及调控肌浆网钙ATP酶表达等。就TFAM的分子生物学结构、生物学功能及调节方面进行综述。
关键词：TFAM；线粒体DNA；转录调节

Progress of mitochondrial transcription factor A

YAO Peng-Cheng， ZHANG Zuo， PENG Shu-Hong^*， ZHOU Jun

(Jiangxi University of Traditional Chinese Medicine， Nanchang 330004， China)

Abstract: Abstract: Mitochondrial transcription factor A(TFAM) is a key regulator， which involves in mitochondrial DNA(mt DNA) transcription and mtDNA copy number. It is encoded by nuclear gene and is transported into mitochondria. TFAM not only regulates mtDNA transcription and mtDNA copy number， but also ameliorates mitochondrial function and regulates sarcoplasmic reticulum Ca2+ ATPase gene transcription. The molecular structure， functions and regulation of TFAM are reviewed in this paper.
Key words: TFAM; mitochondrial DNA; transcription regulation