《生命科学》 2011, 23(5): 429-433

碳酸酐酶III在疾病和肌肉疲劳发生发展中的作用

尚西亮¹，鲍苑苑²，任惠民³，陈世益^1*

(1 复旦大学附属华山医院运动医学科，上海 200040；2 复旦大学附属华山医院内分泌科，上海 200040； 3 复旦大学神经病学研究所，上海 200040)

摘　要：摘　要：碳酸酐酶(carbonic anhydrases，CAs)是一种广泛存在的含锌的金属蛋白酶，能可逆性地高效催化CO2的水合反应，参与调节胞内pH值、离子运输和生物合成反应等多种生理过程。在哺乳动物体内已发现13种CA同工酶和3种CA相关蛋白，其中CAIII与其他CA同工酶相比，在组织分布、分子结构和生物学功能上均有其独特之处。CAIII表达异常可能与多种临床疾病的发生和发展有关，还可能参与了肌肉疲劳的发生。
关键词：碳酸酐酶III；生物学功能；疾病；肌肉疲劳

Effects of CAIII on the occurrence and development of diseases and muscle fatigue

SHANG Xi-Liang¹， BAO Yuan-Yuan²， REN Hui-Min³， CHEN Shi-Yi^1*

(1 Department of Sports Medicine， Huashan Hospital， Fudan University， Shanghai 200040， China;2 Department of Endocrinology， Huashan Hospital， Fudan University， Shanghai 200040， China;3 Institute of Neurology， Fudan University， Shanghai 200040， China)

Abstract: Abstract: Carbonic anhydrases (CAs) are zinc metalloenzymes that catalyze the reversible hydration of CO2 to bicarbonate. They are major players in many physiological processes， including pH regulation and homeostasis， ion transportation， biosynthetic reactions， etc. The CA family consists of 13 different CA isozymes and 3 different CA-related proteins (CARP). Carbonic anhydrase III (CAIII) is one specific member of this family， which distinguished from the other isozymes by tissue distribution， molecular structure and biological functions. In recent years， it has been suggested that the changes of protein levels and activities of CAIII might be related with the occurrence and development of many kinds of diseases and muscle fatigue.
Key words: carbonic anhydrase III; biological functions; diseases; muscle fatigue