《生命科学》 2011, 23(4): 369-375

热休克因子生理功能研究进展

弓　彦^1，2，李国勤1，卢立志^1﹡

(1 浙江省农业科学院畜牧兽医研究所，杭州 310021；2 南京农业大学动物科技学院，南京 210095)

摘　要：摘　要：热休克因子是调控真核细胞热休克基因转录的关键因子，在应激和正常生理条件下发挥重要作用，使其成为近年来的研究热点。该文简要综述热休克因子在抗炎反应、肿瘤发生与维持、生长发育、衰老等生理病理过程中的重要生理功能。
关键词：热休克因子；热休克反应；生理功能；肿瘤

Physiological function of heat shock factors

GONG Yan^1，2， LI Guo-Qin¹， LU Li-Zhi^1*

(1 Institute of Animal Husbandry and Veterinary Science， Zhejiang Academy of Agricultural Sciences， Hangzhou 310021， China; 2 College of Animal Science and Technology， Nanjing Agricultural University， Nanjing 210095， China)

Abstract: Abstract: Heat shock factors (HSFs) are key factors to regulate the transcription of eukaryotic heat shock genes and play important roles in both stress and normal physiological conditions， making them become hotspot recently. This article summarized the physiological functions of HSFs in anti-inflammatory response， tumorigenesis and maintenance， growth， aging and other physiological or pathological processes.
Key words: heat shock factors; heat shock response; physiological functions; tumor