《生命科学》 2011, 23(4): 342-347

NK细胞和NKT细胞发育的转录调控

张秀凤^1，2，周翠红²，张　岩^{2 *}，袁金铎¹

(1 山东师范大学生命科学学院，济南 250014；2 中国科学院上海巴斯德研究所， 中国科学院分子病毒学与免疫学重点实验室，上海 200025)

摘　要：摘　要：自然杀伤(natural killer，NK)细胞和自然杀伤T(natural killer T，NKT)细胞是参与机体抗病毒免疫和肿瘤免疫的两群淋巴细胞亚群，是介导先天性免疫(innate immunity)应答和调节适应性免疫(adaptive immunity)应答的重要效应细胞。近年来，随着对NK细胞和NKT细胞及其转录调控因子研究的不断深入，NK细胞和NKT细胞的发育机制逐步被阐明，这将为提高NK细胞和NKT细胞的抗病毒和肿瘤免疫疗效提供新的策略。
关键词：自然杀伤细胞；自然杀伤T细胞；发育；转录因子

Transcriptional regulation of natural killer cell and natural killer T cell development

ZHANG Xiu-Feng^1，2， ZHOU Cui-Hong²， ZHANG Yan^2*， YUAN Jin-Duo¹

(1 College of Life Sciences， Shandong Normal University， Ji’nan 250014， China; 2 Key Laboratory of Molecular Virology & Immunology， Institut Pasteur of Shanghai， Shanghai Institutes for Biological Sciences， Chinese Academy of Sciences， Shanghai 20002， China)

Abstract: Abstract: Natural killer (NK) cells and natural killer T (NKT) cells are two subsets of lymphocytes that play critical roles in anti-tumor and anti-viral immunity. And NK cells and NKT cells are the important effector cells in innate immunity and adaptive immunity. Recent progress have begun to reveal the transcriptional regulation of NK and NKT cells development， and will benefit the clinical application of NK and NKT cell based therapeutic strategies against tumor and viral infections.
Key words: natural killer cell; natural killer T cell; development; transcription factor